Methyl-gbb

Methyl-gbb has been studied in 1 paper since 2026: none in people yet, 1 in animals; 1 in the past year. The research so far is in animals. The newest story, Oct 19, 2026: “Drug improved survival in mice missing the enzyme statins target”.

Intervention

1 paper studies it4 findingsUpdated

  • 1 lab in 1 country
  • Animals1

What did studies of Methyl-gbb find?

4

Studies of Methyl-gbb measured 4 outcomes; the most studied are long-chain acylcarnitines (1 study), liver injury (1) and hypoglycemia (1).

Long-chain acylcarnitines

downin mice1

1 study
  1. Methyl-gbb decreases long-chain acylcarnitines in mice.

    “methyl-GBB markedly improved survival, prevented hypoglycaemia, reduced liver injury, preserved mitochondrial respiratory function, and normalized hepatic long-chain acylcarnitine profiles.”

    Animalswhole-body Hmgcr-knockout miceliver

    Drug improved survival in mice missing the enzyme statins target

    Research SquarePreprint

More on Long-chain acylcarnitines

Liver injury

downin mice1

1 study
  1. Methyl-gbb decreases liver injury in mice.

    “treatment with the acylcarnitine-lowering agent methyl-GBB markedly improved survival, prevented hypoglycaemia, reduced liver injury”

    Animalswhole-body Hmgcr-knockout miceliver

    Drug improved survival in mice missing the enzyme statins target

    Research SquarePreprint

Hypoglycemia

downin mice1

1 study
  1. Methyl-gbb prevents hypoglycemia in mice.

    “treatment with the acylcarnitine-lowering agent methyl-GBB markedly improved survival, prevented hypoglycaemia”

    Animalswhole-body Hmgcr-knockout mice

    Drug improved survival in mice missing the enzyme statins target

    Research SquarePreprint

More on Hypoglycemia

Survival

upin mice1

1 study
  1. Methyl-gbb increases survival in mice.

    “treatment with the acylcarnitine-lowering agent methyl-GBB markedly improved survival”

    Animalswhole-body Hmgcr-knockout mice

    Drug improved survival in mice missing the enzyme statins target

    Research SquarePreprint

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 11 paper in 12 months
Research Square

Drug improved survival in mice missing the enzyme statins target

In a mouse experiment, the compound also prevented low blood sugar and reduced liver injury after loss of the enzyme blocked by statins.In a mouse experiment, the compound also prevented low blood sugar and reduced liver injury after loss of the enzyme blocked by statins.

Preprint: mouse studyMechanisms