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Mechanical stretch

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab
  • Cells1

Outcomes

2

osteogenesis

upin cells1

1 study

  1. Mechanical stretch improves osteogenesis in cells.

    “Mechanical stretch significantly upregulated CXCR4, downregulated p16, p21 and p53, reduced the senescence-associated β-galactosidase (SA-β-gal)-positive cells, suppressed the senescence-associated secretory phenotype (SASP), and restored osteogenic potential”

    Cellsin D-galactose-induced premature MSCs

    Mechanical Stretch Prevents Senescence-Associated Osteogenic Impairment in Mesenchymal Stem Cells via CXCR4/PI3K/AKT Signaling

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology30 Oct 2025

Senescence-associated beta-galactosidase

downin cells1

1 study

  1. Mechanical stretch decreases senescence-associated beta-galactosidase in cells.

    “Mechanical stretch significantly upregulated CXCR4, downregulated p16, p21 and p53, reduced the senescence-associated β-galactosidase (SA-β-gal)-positive cells, suppressed the senescence-associated secretory phenotype (SASP), and restored osteogenic potential”

    Cellsin D-galactose-induced premature MSCs

    Mechanical Stretch Prevents Senescence-Associated Osteogenic Impairment in Mesenchymal Stem Cells via CXCR4/PI3K/AKT Signaling

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology30 Oct 2025

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