Meal

Intervention

3 papers6 findings

  • 2 independent labs in 2 countries
  • Funders: Japan Society for the Promotion of Science and 6 more
  • Human trial2
  • Humans1

Outcomes

6

pTau181/

no changein humans1

1 study
  1. Meal has no effect on pTau181/ in humans.

    “Results provided strong and very strong evidence for no changes in Aβ42/40 ratio and pTau181, respectively.”

    Human trialpost-prandialplasman = 30

    EFFECTS OF FASTING STATUS ON BLOOD-BASED NEURODEGENERATIVE BIOMARKERS IN OLDER ADULTS

    GSA 2024 abstract31 Dec 2024

More on pTau181/

Aβ42:40 ratio

no changein humans1

1 study
  1. Meal has no effect on Aβ42:40 ratio in humans.

    “Results provided strong and very strong evidence for no changes in Aβ42/40 ratio and pTau181”

    Human trialpost-prandialplasman = 30

    EFFECTS OF FASTING STATUS ON BLOOD-BASED NEURODEGENERATIVE BIOMARKERS IN OLDER ADULTS

    GSA 2024 abstract31 Dec 2024

More on Aβ42:40 ratio

NfL

downin humans1

1 study
  1. Meal decreases NfL in humans.

    “weak evidence that eating decreased NfL levels”

    Human trialpost-prandialplasman = 30

    EFFECTS OF FASTING STATUS ON BLOOD-BASED NEURODEGENERATIVE BIOMARKERS IN OLDER ADULTS

    GSA 2024 abstract31 Dec 2024

More on NfL

pTau217

downin humans1

1 study
  1. Meal decreases pTau217 in humans.

    “substantial evidence that eating decreased pTau217 levels”

    Human trialpost-prandialplasman = 30

    EFFECTS OF FASTING STATUS ON BLOOD-BASED NEURODEGENERATIVE BIOMARKERS IN OLDER ADULTS

    GSA 2024 abstract31 Dec 2024

More on pTau217

GFAP

downin humans1

1 study
  1. Meal decreases GFAP in humans.

    “there was very strong evidence that eating decreased GFAP levels”

    Human trialpost-prandialplasman = 30

    EFFECTS OF FASTING STATUS ON BLOOD-BASED NEURODEGENERATIVE BIOMARKERS IN OLDER ADULTS

    GSA 2024 abstract31 Dec 2024

More on GFAP

Nampt serum concentration

no changein humans1

1 study
  1. Meal has no effect on Nampt serum concentration in humans.

    “Meals did not influence Nampt serum levels”

    HumansHealthy individuals with normal weight or obesityserum

    Diurnal rythm of Nampt is gender and weight dependent

    Obesity research & clinical practice1 May 2024

More on Nampt serum concentration

Funding

10 grants since 2016

Japan Society for the Promotion of ScienceJP¥12mNorges ForskningsrådNOK 2.8mMedical Research Future FundA$1.5m

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