Meal
3 papers6 findings
- 2 independent labs in 2 countries
- Funders: Japan Society for the Promotion of Science and 6 more
- Human trial2
- Humans1
Outcomes
6pTau181/
no changein humans1
1 study
pTau181/
no changein humans1
Meal has no effect on pTau181/ in humans.
“Results provided strong and very strong evidence for no changes in Aβ42/40 ratio and pTau181, respectively.”
Human trialpost-prandialplasman = 30
EFFECTS OF FASTING STATUS ON BLOOD-BASED NEURODEGENERATIVE BIOMARKERS IN OLDER ADULTS
GSA 2024 abstract31 Dec 2024
Aβ42:40 ratio
no changein humans1
1 study
Aβ42:40 ratio
no changein humans1
Meal has no effect on Aβ42:40 ratio in humans.
“Results provided strong and very strong evidence for no changes in Aβ42/40 ratio and pTau181”
Human trialpost-prandialplasman = 30
EFFECTS OF FASTING STATUS ON BLOOD-BASED NEURODEGENERATIVE BIOMARKERS IN OLDER ADULTS
GSA 2024 abstract31 Dec 2024
NfL
downin humans1
1 study
NfL
downin humans1
Meal decreases NfL in humans.
“weak evidence that eating decreased NfL levels”
Human trialpost-prandialplasman = 30
EFFECTS OF FASTING STATUS ON BLOOD-BASED NEURODEGENERATIVE BIOMARKERS IN OLDER ADULTS
GSA 2024 abstract31 Dec 2024
pTau217
downin humans1
1 study
pTau217
downin humans1
Meal decreases pTau217 in humans.
“substantial evidence that eating decreased pTau217 levels”
Human trialpost-prandialplasman = 30
EFFECTS OF FASTING STATUS ON BLOOD-BASED NEURODEGENERATIVE BIOMARKERS IN OLDER ADULTS
GSA 2024 abstract31 Dec 2024
GFAP
downin humans1
1 study
GFAP
downin humans1
Meal decreases GFAP in humans.
“there was very strong evidence that eating decreased GFAP levels”
Human trialpost-prandialplasman = 30
EFFECTS OF FASTING STATUS ON BLOOD-BASED NEURODEGENERATIVE BIOMARKERS IN OLDER ADULTS
GSA 2024 abstract31 Dec 2024
Nampt serum concentration
no changein humans1
1 study
Nampt serum concentration
no changein humans1
Meal has no effect on Nampt serum concentration in humans.
“Meals did not influence Nampt serum levels”
HumansHealthy individuals with normal weight or obesityserum
Diurnal rythm of Nampt is gender and weight dependent
Obesity research & clinical practice1 May 2024
Funding
10 grants since 2016Japan Society for the Promotion of ScienceJP¥12mNorges ForskningsrådNOK 2.8mMedical Research Future FundA$1.5m
Advancing Dysphagia Rehabilitation: Validation of the "Miraggio" Meal Simulation System
Japan Society for the Promotion of ScienceKitasato UniversityJP¥4.7m2025–2028
Early detection of insulin-resistance with a mixed meal challenge - The REFINE study
Department of Health, Australian GovernmentDeakin UniversityA$1.5m2023–2026
Early detection of insulin-resistance with a mixed meal challenge - The REFINE study
Medical Research Future FundDeakin UniversityA$1.5m2023–2027
American Diabetes AssociationMassachusetts General Hospital2022–2024
Agence Nationale de la RechercheVrije Universiteit Brussel€347.3k2021
Norges ForskningsrådNofimaNOK 2.8m2021–2026
Japan Society for the Promotion of ScienceTezukayama UniversityJP¥4.4m2018–2022
Association between meal pattern and frailty in community-dwelling older Japanese
Japan Society for the Promotion of ScienceTokyo Metropolitan Geriatric HospitalJP¥2.9m2016–2018