Matrix-restorative agent

Matrix-restorative agent decreases senolytic dose required for a target outcome in silico (Roughly one-third lower required senolytic dose).

“A senolytic combined with a matrix-restorative agentis synergistic by the Bliss criterion and dose-sparing, lowering the senolytic dose needed fora target outcome by roughly one third.”

In silicoCombined with senolytics in simulations using illustrative parameters; synergy assessed by the Bliss criterion

Reversing Cellular Senescence and Extracellular Matrix Degeneration: A Multiscale Model of Senolytic Intervention and Verifiable Recovery Predictions

Zenodo (CERN European Organization for Nuclear Research)·1 Aug 2026Preprint