AgingResearch.NewsJoin free

Low-protein calorie-restricted diet

Intervention

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Animals1

Outcomes

5

NLRP3

downin mice1

1 study

  1. Low-protein calorie-restricted diet decreases NLRP3 in mice (p < 0.01).

    “reductions in serum tumor necrosis factor-α (TNF-α) levels (20.75 ± 7.83 μmol/L vs. 5.37 ± 2.45 μmol/L; p < 0.01) and apoptosis-associated speck-like protein containing a CARD (ASC), NOD-like receptor family pyrin domain containing 3 (NLRP3), and interleukin-1β (IL-1β) expression in kidney tissue (all p < 0.01).”

    Animalsdiabetic micekidney5 weeks

    Low-protein Calorie-restriction Mitigates Diabetic Mice Kidney Injury via the Gut-Kidney Axis

    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition27 Aug 2025

More on NLRP3

TNF-alpha

downin mice1

1 study

  1. Low-protein calorie-restricted diet decreases TNF-alpha in mice (20.75 ± 7.83 μmol/L vs. 5.37 ± 2.45 μmol/L; p < 0.01).

    “exhibited significant reductions in serum tumor necrosis factor-α (TNF-α) levels (20.75 ± 7.83 μmol/L vs. 5.37 ± 2.45 μmol/L; p < 0.01)”

    Animalsdiabetic mice5 weeks

    Low-protein Calorie-restriction Mitigates Diabetic Mice Kidney Injury via the Gut-Kidney Axis

    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition27 Aug 2025

More on TNF-alpha

Trimethylamine n-oxide

downin mice1

1 study

  1. Low-protein calorie-restricted diet decreases trimethylamine n-oxide in mice (67.51 ± 1.47 ng/mL vs. 56.58 ± 5.75 ng/mL; p < 0.01).

    “decreasing serum trimethylamine oxide levels (67.51 ± 1.47 ng/mL vs. 56.58 ± 5.75 ng/mL; p < 0.01)”

    Animalsdiabetic mice5 weeks

    Low-protein Calorie-restriction Mitigates Diabetic Mice Kidney Injury via the Gut-Kidney Axis

    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition27 Aug 2025

More on Trimethylamine n-oxide

Fasting blood glucose

downin mice1

1 study

  1. Low-protein calorie-restricted diet decreases fasting blood glucose in mice (p < 0.01).

    “improved glycemic control (fasting blood glucose: p < 0.01)”

    Animalsdiabetic mice5 weeks

    Low-protein Calorie-restriction Mitigates Diabetic Mice Kidney Injury via the Gut-Kidney Axis

    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition27 Aug 2025

More on Fasting blood glucose

Kidney damage

downin mice1

1 study

  1. Low-protein calorie-restricted diet decreases kidney damage in mice.

    “The low-protein calorie-restricted diet significantly improved glycemic control (fasting blood glucose: p < 0.01), ameliorated dyslipidemia (all p < 0.01), and mitigated kidney damage in diabetic mice.”

    Animalsdiabetic micekidney5 weeks

    Low-protein Calorie-restriction Mitigates Diabetic Mice Kidney Injury via the Gut-Kidney Axis

    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition27 Aug 2025

Latest

Related