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Low-protein diet

Intervention

4 papers5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 2 independent labs in 2 countries
  • Funder: Grantová Agentura České Republiky
  • Animals4

Outcomes

5

Fertilization rate

no changein killifish1

1 study

  1. Low-protein diet has no effect on fertilization rate in killifish.

    “Only the low-protein diet with 22% lipids supported a comparable fertilization rate to the control group.”

    Animalslow-protein diet with 22% lipids5 months

    First attempt at using a synthetic diet in short-lived killifish, a vertebrate model of ageing

    Journal of fish biology27 Oct 2025

Defferibacterota

downin mice1

1 study

  1. Low-protein diet decreases Defferibacterota in mice.

    “Relative abundances of Bacteroides and Defferibacterota were reduced in LP diets”

    Animals20-weeksfemalesn = 12

    IMPACT OF LOW PROTEIN DIETS ON GUT HEALTH

    GSA 2024 abstract31 Dec 2024

Bacteroides

downin mice1

1 study

  1. Low-protein diet decreases Bacteroides in mice.

    “Relative abundances of Bacteroides and Defferibacterota were reduced in LP diets”

    Animals20-weeksfemalesn = 12

    IMPACT OF LOW PROTEIN DIETS ON GUT HEALTH

    GSA 2024 abstract31 Dec 2024

Verrucomicrobiota

upin mice1

1 study

  1. Low-protein diet increases Verrucomicrobiota in mice.

    “increased in Verrucomicrobiota.”

    Animals20-weeksfemalesn = 12

    IMPACT OF LOW PROTEIN DIETS ON GUT HEALTH

    GSA 2024 abstract31 Dec 2024

Glucose clearance

upin mice1

1 study

  1. Low-protein diet improves glucose clearance in mice.

    “we show that aging female have improved glucose clearance during LP-diet.”

    Animals20-weeksfemalesn = 12

    IMPACT OF LOW PROTEIN DIETS ON GUT HEALTH

    GSA 2024 abstract31 Dec 2024

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