Lobetyolin

1. Lobetyolin decreases reactive oxygen species in worms (-28.1 ± 8.9%).

   “intracellular ROS declined maximally by 28.1 ± 8.9% (N2) and 22.4 ± 3.8% (CL4176).”

   Model organismswild-type N2 worms12.5-50 μM

   Lobetyolin, an anti-AD factor from the diet campanulaceae source, metabolism regulation and target exploration

   Natural products and bioprospecting·12 Sep 2025

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1. Lobetyolin extends lifespan in worms (up to 25.0%).

   “Lifespan increased by up to 18.2% in CL4176 and 25.0% in wild-type N2 worms.”

   Model organismswild-type N2 worms12.5-50 μM

   Lobetyolin, an anti-AD factor from the diet campanulaceae source, metabolism regulation and target exploration

   Natural products and bioprospecting·12 Sep 2025

1. Lobetyolin decreases paralysis in worms (delayed by 20.9 ± 4.5%).

   “paralysis in CL4176 was delayed by 20.9 ± 4.5%.”

   Model organismsin CL4176 worms12.5-50 μM

   Lobetyolin, an anti-AD factor from the diet campanulaceae source, metabolism regulation and target exploration

   Natural products and bioprospecting·12 Sep 2025

1. Lobetyolin decreases amyloid-beta in worms (-54.8 ± 9.4%).

   “In CL2006 worms, β-amyloid deposits fell by 54.8 ± 9.4%”

   Model organismsin CL2006 worms12.5-50 μM

   Lobetyolin, an anti-AD factor from the diet campanulaceae source, metabolism regulation and target exploration

   Natural products and bioprospecting·12 Sep 2025

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