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Liposomal clodronate

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: King Saud University
  • Animals1

Outcomes

3

Cellular senescence

downin rats1

1 study

  1. Liposomal clodronate decreases cellular senescence in rats.

    “In conclusion, macrophage depletion combats kidney senescence by modulating Klotho and GDF-15”

    Animalsin diabetic ratskidney

    Macrophage Depletion Alleviates Immunosenescence in Diabetic Kidney by Modulating GDF-15 and Klotho

    International journal of molecular sciences23 Apr 2025

More on Cellular senescence

KL

upin rats1

1 study

  1. Liposomal clodronate increases KL in rats.

    “Additionally, LC treatment promoted macrophage polarization towards the anti-inflammatory phenotype, downregulated GDF-15 expression, upregulated Klotho expression, and ameliorated kidney damage.”

    Animalsin diabetic ratskidney4 weeks

    Macrophage Depletion Alleviates Immunosenescence in Diabetic Kidney by Modulating GDF-15 and Klotho

    International journal of molecular sciences23 Apr 2025

More on KL

Kidney damage

downin rats1

1 study

  1. Liposomal clodronate decreases kidney damage in rats.

    “Additionally, LC treatment promoted macrophage polarization towards the anti-inflammatory phenotype, downregulated GDF-15 expression, upregulated Klotho expression, and ameliorated kidney damage.”

    Animalsin diabetic ratskidney4 weeks

    Macrophage Depletion Alleviates Immunosenescence in Diabetic Kidney by Modulating GDF-15 and Klotho

    International journal of molecular sciences23 Apr 2025

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