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GeroScience·27 Dec

Centenarians-the way to healthy vascular ageing and longevity: a review from VascAgeNet

ReviewMechanisms

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Epigenetic regulation of gene expression1
Immune response1
Microbiome composition1
Oxidative stress and ROS signalling1
Cardiovascular disease1

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Lilly’s retatrutide achieves 18.8% weight loss in obesity and type 2 diabetesTrialsMedical Xpress and 4 more

Human ovaries keep remodeling with increasing inflammation decades after menopause, researchers reportResearchMedical Xpress and 3 more

Rubedo reports RLS-1496 lowers measured skin epigenetic age 2.1 years in atopic dermatitisTrialsLongevity.Technology and 1 more

Trials

Fatigability of Lower Limb Muscle in Older Adults: Protective Effects of Strength Training Exercise in Old Men and WomenResults posted 13 Oct 2026, Marquette University Fisetin for Improving Vascular Function in Older Adults: A Phase II Clinical TrialPhase 2Registered 13 Oct 2026, University of Colorado, Boulder ELITE: Deep Profiling and Algorithmic Polytherapy to Map Individual Response in Healthy AgingPhase 2Registered 13 Oct 2026, Sheba Medical Center

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