Levilactobacillus brevis

1. Levilactobacillus brevis extends lifespan in worms (wild-type N2 background) (+28.6% mean lifespan).

   “Dietary supplementation with MKMB04 and MKMB05 significantly extended the mean lifespan of wild-type N2 worms by 28.6% and 17.9%, respectively”

   Model organismswild-type N2 backgroundMKMB04

   Two bacterial strains extended lifespan in worms

   Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·May 8, 2026

2. Levilactobacillus brevis extends lifespan in worms (standard laboratory conditions).

   “Live L. brevis and W. coagulans significantly extended the lifespan of C. elegans under standard laboratory conditions independently of dietary restrictions.”

   Model organismsstandard laboratory conditionslive

   Geroprotective Effect of Levilactobacillus brevis and Weizmannia coagulans in Caenorhabditis elegans

   Probiotics and antimicrobial proteins·Apr 10, 2023

3. Levilactobacillus brevis extends lifespan in worms.

   “Also, live L. brevis MTCC 1750 could prolong the worm's lifespan.”

   Model organismslive

   Lactobacillus brevis MTCC 1750 enhances oxidative stress resistance and lifespan extension with improved physiological and functional capacity in Caenorhabditis elegans via the DAF-16 pathway

   Free radical research·Dec 9, 2022

1. Levilactobacillus brevis decreases pro-inflammatory cytokines in worm cells (Salmonella challenge in intestinal and immune cell models).

   “pro-inflammatory cytokines (TNF-α, IL-6, IL-1β and MCP-1) were suppressed”

   CellsSalmonella challenge in intestinal and immune cell modelsMKMB04 and MKMB05

   Two bacterial strains extended lifespan in worms

   Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·May 8, 2026

More on Pro-inflammatory cytokines

1. Levilactobacillus brevis increases catalase in worms.

   “MKMB04 markedly enhanced endogenous antioxidant defenses, as evidenced by increased catalase activity and glutathione levels”

   Model organismsMKMB04

   Two bacterial strains extended lifespan in worms

   Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·May 8, 2026

More on Catalase

1. Levilactobacillus brevis improves intestinal integrity in worms.

   “We found that L. brevis and W. coagulans enhanced the intestinal integrity and intestinal barrier functions without affecting the overall physiological functions of C. elegans.”

   Model organisms

   Geroprotective Effect of Levilactobacillus brevis and Weizmannia coagulans in Caenorhabditis elegans

   Probiotics and antimicrobial proteins·Apr 10, 2023

1. Levilactobacillus brevis improves physical function in worms.

   “This also explained the significant improvements in different age-associated changes in physiological and mechanical parameters of the worm by L. brevis MTCC 1750.”

   Model organisms

   Lactobacillus brevis MTCC 1750 enhances oxidative stress resistance and lifespan extension with improved physiological and functional capacity in Caenorhabditis elegans via the DAF-16 pathway

   Free radical research·Dec 9, 2022

1. Levilactobacillus brevis decreases reactive oxygen species in worms (against juglone induced oxidative stress).

   “Lactobacillus brevis MTCC 1750 could enhance the resistance of C. elegans against juglone induced oxidative stress by reducing its intracellular reactive oxygen species (ROS) accumulation.”

   Model organismsagainst juglone induced oxidative stress

   Lactobacillus brevis MTCC 1750 enhances oxidative stress resistance and lifespan extension with improved physiological and functional capacity in Caenorhabditis elegans via the DAF-16 pathway

   Free radical research·Dec 9, 2022

More on Reactive oxygen species