Lauric acid

1. Lauric acid decreases liver injury in mice.

   “LA restored bile acid homeostasis and Farnesoid X receptor-LRH-1 signaling in the liver and ileum, reduced oxidative stress, and normalized cholestasis-related gene expression in conjunction with improved liver injury, inflammation, and ductular reaction.”

   Animalsin 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholangiopathyliver20%3 daysmales

   Dietary Lauric Acid Suppresses Inflammation, Cholestasis, Hepatocyte Injury, and Senescence in 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-induced Inflammatory Cholangiopathy

   Cellular and molecular gastroenterology and hepatology·20 Jan 2026

1. Lauric acid decreases oxidative stress and ROS signalling in mice.

   “LA restored bile acid homeostasis and Farnesoid X receptor-LRH-1 signaling in the liver and ileum, reduced oxidative stress”

   Animalsin 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholangiopathyliver20%3 daysmales

   Dietary Lauric Acid Suppresses Inflammation, Cholestasis, Hepatocyte Injury, and Senescence in 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-induced Inflammatory Cholangiopathy

   Cellular and molecular gastroenterology and hepatology·20 Jan 2026

More on Oxidative stress and ROS signalling

1. Lauric acid inhibits cellular senescence in mice.

   “DDC mice exhibited enhanced hepatocyte senescence (upregulated Cdkn1a, Cdkn1b, Ccl2) and signal transducer and activator of transcription (STAT) 1 activation, all of which were attenuated by LA.”

   Animalsin 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholangiopathyliver20%3 daysmales

   Dietary Lauric Acid Suppresses Inflammation, Cholestasis, Hepatocyte Injury, and Senescence in 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-induced Inflammatory Cholangiopathy

   Cellular and molecular gastroenterology and hepatology·20 Jan 2026

More on Cellular senescence