Cholecystectomy

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: Korea Health Industry Development Institute and 3 more
2 of 3 findings with company ties

Humans2

Associations

Dementia

upin humans1HR 1.071

1 study

Cholecystectomy raises the risk of dementia in humans (HR 1.071 (95% CI, 1.048-1.095)).
“This modest but statistically significant increase in the hazard of dementia in the cholecystectomy group remained consistent after model adjustment (1.071; 95% CI, 1.048-1.095; P < 0.001)”
Humansafter model adjustment2013 to 2022n = 227,987
Risk of Dementia After Cholecystectomy in Older Adults: A Nationwide Retrospective Study
Journal of Korean medical science21 Sep 2026