Lactucopicrin

1. Lactucopicrin activates autophagy in mice.

   “LCP enhances ZDHHC4-catalyzed palmitoylation of the cargo receptor CCDC50, facilitating the selective autophagic degradation of MAP2K4/MKK4”

   Animals

   Lactucopicrin promotes the autophagic degradation of MAP2K4/MKK4 by mediating CCDC50 palmitoylation to alleviate osteoarthritis progression

   Autophagy·21 Jan 2026

More on Autophagy

1. Lactucopicrin decreases cellular senescence in mice.

   “facilitating the selective autophagic degradation of MAP2K4/MKK4, leading to the suppression of MAPK/JNK signaling and the attenuation of chondrocyte senescence”

   Animals

   Lactucopicrin promotes the autophagic degradation of MAP2K4/MKK4 by mediating CCDC50 palmitoylation to alleviate osteoarthritis progression

   Autophagy·21 Jan 2026

More on Cellular senescence

1. Lactucopicrin decreases cartilage degeneration in mice.

   “by reducing cartilage degeneration and preserving matrix integrity”

   Animalsdestabilization of the medial meniscus

   Lactucopicrin promotes the autophagic degradation of MAP2K4/MKK4 by mediating CCDC50 palmitoylation to alleviate osteoarthritis progression

   Autophagy·21 Jan 2026

1. Lactucopicrin lowers the risk of osteoarthritis in mice.

   “lactucopicrin (LCP) as an effective autophagy activator that alleviates OA progression in a mouse model induced by the destabilization of the medial meniscus”

   Animalsdestabilization of the medial meniscus

   Lactucopicrin promotes the autophagic degradation of MAP2K4/MKK4 by mediating CCDC50 palmitoylation to alleviate osteoarthritis progression

   Autophagy·21 Jan 2026

More on Osteoarthritis