AgingResearch.NewsJoin free

Lactobacillus amylovorus

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Ministry of Science and ICT, South Korea and 2 more
  • Animals1

Outcomes

2

Senescence-associated secretory phenotype (SASP)

downin mice1

1 study

  1. Lactobacillus amylovorus decreases senescence-associated secretory phenotype (SASP) in mice.

    “Both LKU4 and NDN consistently reduced the senescence-associated secretory phenotype (SASP) in the AT of aged mice”

    Animalsadipose tissue

    Lactobacillus amylovorus KU4 inhibits adipocyte senescence in aged mice through necdin regulation of p53 activity

    Aging3 Sep 2025

More on Senescence-associated secretory phenotype (SASP)

Aging phenotypes

downin mice1

1 study

  1. Lactobacillus amylovorus decreases aging phenotypes in mice.

    “LKU4 administration suppresses age-related metabolic dysfunction and aging phenotypes in AT of 24-month-old mice.”

    Animalsadipose tissue

    Lactobacillus amylovorus KU4 inhibits adipocyte senescence in aged mice through necdin regulation of p53 activity

    Aging3 Sep 2025

Upstream

1

NDN

is required forin mice1

1 study

  1. NDN is required for lactobacillus amylovorus in mice.

    “ex vivo NDN silencing in the AT of D-galactose-induced aging mice abolished LKU4 protection against p53-induced adipose senescence”

    Animalsin D-galactose-induced aging miceadipose tissue

    Lactobacillus amylovorus KU4 inhibits adipocyte senescence in aged mice through necdin regulation of p53 activity

    Aging3 Sep 2025

More on NDN

Latest

Related