KU-60019

4 papers10 findings

Outcomes

Cellular senescence

downin cells1upin human cells1

2 studies

KU-60019 induces cellular senescence in human cells.
“KU60019, that promotes both maturation-associated features and senescence-associated phenotypes in hiPSC-derived neurons and fibroblasts”
Cellsin hiPSC-derived neurons and fibroblasts
Suppression of ATM kinase signaling accelerates cellular senescence
Stem cell reportsJun 11, 2026
KU-60019 decreases cellular senescence in cells.
“Pharmacological inhibition of ATM with KU60019 strongly attenuated nucleolar stress-induced β cell senescence.”
Cellsin cultured beta cells exposed to nucleolar stress
Nucleolar stress facilitates islet β cell senescence via hijacking the DNA damage response pathways
iScienceSep 4, 2025

Lifespan

downin D. kikkawai1upin D. virilis1upin flies1

1 study

KU-60019 shortens lifespan in D. kikkawai.
“However, the lifespan was reduced after KU-60019 treatment in the short-lived species D. kikkawai.”
Model organisms
Geroprotective Properties of the ATM Inhibitor KU-60019 in Three Drosophila Species Differing in Lifespan
Molekuliarnaia biologiiaJan 1, 2024
KU-60019 extends lifespan in D. virilis.
“KU-60019 was shown to increase the lifespan in the long-lived species D. virilis and moderate-lifespan D. melanogaster.”
Model organisms
Geroprotective Properties of the ATM Inhibitor KU-60019 in Three Drosophila Species Differing in Lifespan
Molekuliarnaia biologiiaJan 1, 2024
KU-60019 extends lifespan in flies.
“KU-60019 was shown to increase the lifespan in the long-lived species D. virilis and moderate-lifespan D. melanogaster.”
Model organisms
Geroprotective Properties of the ATM Inhibitor KU-60019 in Three Drosophila Species Differing in Lifespan
Molekuliarnaia biologiiaJan 1, 2024

Disease-relevant phenotypes

upin human cells1

1 study

KU-60019 increases disease-relevant phenotypes in human cells.
“KU60019 treatment promoted the manifestation of disease-relevant phenotypes in hiPSC models of age-related neurodegenerative diseases.”
Cellsin hiPSC models of age-related neurodegenerative diseases
Suppression of ATM kinase signaling accelerates cellular senescence
Stem cell reportsJun 11, 2026

Neuronal maturation

upin human cells1

1 study

KU-60019 increases neuronal maturation in human cells.
“KU60019, that promotes both maturation-associated features and senescence-associated phenotypes in hiPSC-derived neurons and fibroblasts”
Cellsin hiPSC-derived neurons and fibroblasts
Suppression of ATM kinase signaling accelerates cellular senescence
Stem cell reportsJun 11, 2026

Myocardial damage

downin mice1

1 study

KU-60019 decreases myocardial damage in mice.
“In vivo validation using murine LPS-induced sepsis models confirmed significant myocardial damage, which was alleviated by treatment with KU60019”
Animalsin LPS-induced septic mice
Validation of Senescence of the Role of ATM/P53 Pathway in Myocardial Senescence in Mice with Sepsis
Infection and drug resistanceApr 19, 2025

Locomotor activity

no changein flies1

1 study

KU-60019 has no effect on locomotor activity in flies.
“had no effect on age-dependent changes in locomotor activity.”
Model organisms
Geroprotective Properties of the ATM Inhibitor KU-60019 in Three Drosophila Species Differing in Lifespan
Molekuliarnaia biologiiaJan 1, 2024

Healthspan

upin flies1

1 study

KU-60019 improves healthspan in flies.
“KU-60019 was found to increase the survival in hyperthermia, oxidative stress, and starvation in all of the three Drosophila species”
Model organismshyperthermia, oxidative stress, and starvation
Geroprotective Properties of the ATM Inhibitor KU-60019 in Three Drosophila Species Differing in Lifespan
Molekuliarnaia biologiiaJan 1, 2024