Isoflurane anesthesia and laparotomy
1 paper4 findings
- 1 lab in 1 country
- Funder: National Institutes of Health
- Animals1
Outcomes
4Extracellular vesicle protein cargo
upin mice1
1 study
Extracellular vesicle protein cargo
upin mice1
Isoflurane anesthesia and laparotomy induces extracellular vesicle protein cargo in mice.
“extensive remodeling of EV protein cargo enriched for inflammatory and growth factor-related signatures.”
Animalsgeriatric C57BL/6 micecirculating extracellular vesicles24 h after 2 h exposuremales
GeroScience13 May 2026
immune and inflammatory signaling
upin mice1
1 study
immune and inflammatory signaling
upin mice1
Isoflurane anesthesia and laparotomy increases immune and inflammatory signaling in mice.
“Late middle-aged mice exhibited amplified immune and inflammatory signaling in the lung and spleen”
Animalslate middle-aged C57BL/6 micelung and spleen24 h after 2 h exposuremales
GeroScience13 May 2026
lipid, synaptic, and structural maintenance programs
downin mice1
1 study
lipid, synaptic, and structural maintenance programs
downin mice1
Isoflurane anesthesia and laparotomy decreases lipid, synaptic, and structural maintenance programs in mice.
“Late middle-aged mice exhibited robust activation of stress- and metabolism-associated pathways in the OB and HI, accompanied by suppression of lipid, synaptic, and structural maintenance programs.”
Animalslate middle-aged C57BL/6 miceolfactory bulb and hippocampus24 h after 2 h exposuremales
GeroScience13 May 2026
Multiorgan transcriptional remodeling
upin mice1
1 study
Multiorgan transcriptional remodeling
upin mice1
Isoflurane anesthesia and laparotomy induces multiorgan transcriptional remodeling in mice.
“Short-term ISO/OP elicited pronounced, age-dependent transcriptional remodeling across tissues.”
AnimalsC57BL/6 mice; age-dependent responsesolfactory bulb, hippocampus, lung, and spleen24 h after 2 h exposuremales
GeroScience13 May 2026