Ipsc-conditioned medium

Intervention

1 paper4 findings

  • 1 lab in 1 country
  • Funder: Narodowe Centrum Nauki
  • Cells1

Outcomes

4

COMP

downin human cells1

1 study
  1. Ipsc-conditioned medium decreases COMP in human cells.

    “CM and CM + SF have caused a considerable decline in COL1A1 (p = 0.1756), COMP (p = 0.0062), and COL10A1 (p = 0.0250) production”

    Cellsalone or with SF

    iPSC-conditioned medium mitigates the adverse effects of osteoarthritic synovial fluid on chondrocyte cultures

    Biochemical and biophysical research communications10 Jul 2025

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Oxidative stress and ROS signalling

downin human cells1

1 study
  1. Ipsc-conditioned medium decreases oxidative stress and ROS signalling in human cells.

    “ROS production was significantly lower in CM + SF cultures (p = 0.0070).”

    Cellswith SF

    iPSC-conditioned medium mitigates the adverse effects of osteoarthritic synovial fluid on chondrocyte cultures

    Biochemical and biophysical research communications10 Jul 2025

More on Oxidative stress and ROS signalling

Cellular senescence

downin human cells1

1 study
  1. Ipsc-conditioned medium decreases cellular senescence in human cells.

    “CMs, alone or with SF, enhanced proliferation (ANOVA - p < 0.0001) and reduced the senescent cell percentage (Young: p = 0.0044; Senescent: p = 0.0021) compared to controls.”

    Cellsalone or with SF

    iPSC-conditioned medium mitigates the adverse effects of osteoarthritic synovial fluid on chondrocyte cultures

    Biochemical and biophysical research communications10 Jul 2025

More on Cellular senescence

Proliferation

upin human cells1

1 study
  1. Ipsc-conditioned medium increases proliferation in human cells.

    “CMs, alone or with SF, enhanced proliferation (ANOVA - p < 0.0001) and reduced the senescent cell percentage”

    Cellsalone or with SF

    iPSC-conditioned medium mitigates the adverse effects of osteoarthritic synovial fluid on chondrocyte cultures

    Biochemical and biophysical research communications10 Jul 2025

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