Intermittent calorie restriction
2 papers4 findings
- 2 independent labs in 2 countries
- 1 finding against
- Funders: National Major Science and Technology Projects of China and others
- Human trial1
- Animals1
Outcomes
3Liver fat content
no changein humans1downin humans1
1 study
Liver fat content
no changein humans1downin humans1
Intermittent calorie restriction has no effect on liver fat content in humans (P = 0.15).
“Changes in LFC were not significantly different between the 2 groups (P = 0.15)”
Human trialcompared with continuous calorie restriction in adults with MASLDliver12-wkn = 60
The American journal of clinical nutrition22 Oct 2024
Intermittent calorie restriction decreases liver fat content in humans (-20.5% [95% CI: -25.0, -15.9%]).
“The mean reduction in LFC was -20.5% [95% confidence interval (CI): -25.0, -15.9%] in the ICR group”
Human trialin adults with MASLD and abnormal glucose metabolismliver2 successive days of fasting [∼500 kcal/d] and 5 d of recovery per week12-wkn = 60
The American journal of clinical nutrition22 Oct 2024
Insulin resistance
upin mice1
1 study
Insulin resistance
upin mice1
Intermittent calorie restriction improves insulin resistance in mice.
“In contrast, ICR markedly attenuated these abnormalities by restoring lipid and inflammatory profiles, improving insulin sensitivity (lower HOMA-IR and higher QUICKI)”
Animalsin organochlorine pesticide mixture-exposed mice on high-fat diet12 weeks
Journal of hazardous materials4 Jun 2026
Fat mass
downin humans1
1 study
Fat mass
downin humans1
Intermittent calorie restriction decreases fat mass in humans.
“the ICR was associated with greater reductions in fat mass and glycosylated hemoglobin.”
Human trialexploratory endpoints compared to CCR12-wkn = 60
The American journal of clinical nutrition22 Oct 2024