Inokosterone

1. Inokosterone decreases oxidative stress and ROS signalling in mammals cells.

   “The ROS, malondialdehyde (MDA) were significantly decreased, and the autophagosomes in mammalian cells were obviously increased after inokosterone treatment.”

   Cellsmammalian cells

   Inokosterone from Gentiana rigescens Franch Extends the Longevity of Yeast and Mammalian Cells via Antioxidative Stress and Mitophagy Induction

   Antioxidants (Basel, Switzerland)·23 Jan 2022

2. Inokosterone decreases oxidative stress and ROS signalling in yeast cells.

   “Meanwhile, the reactive oxygen species (ROS) and lipid peroxidation of yeast were obviously decreased.”

   Cells

   Inokosterone from Gentiana rigescens Franch Extends the Longevity of Yeast and Mammalian Cells via Antioxidative Stress and Mitophagy Induction

   Antioxidants (Basel, Switzerland)·23 Jan 2022

More on Oxidative stress and ROS signalling

1. Inokosterone increases autophagosomes in mammals cells.

   “The ROS, malondialdehyde (MDA) were significantly decreased, and the autophagosomes in mammalian cells were obviously increased after inokosterone treatment.”

   Cellsmammalian cells

   Inokosterone from Gentiana rigescens Franch Extends the Longevity of Yeast and Mammalian Cells via Antioxidative Stress and Mitophagy Induction

   Antioxidants (Basel, Switzerland)·23 Jan 2022

More on Autophagosomes

1. Inokosterone increases autophagy in yeast cells.

   “Additionally, the macroautophagy and mitophagy in YOM38-GFP-ATG8 yeast were increased upon inokosterone treatment, respectively.”

   CellsYOM38-GFP-ATG8 yeast

   Inokosterone from Gentiana rigescens Franch Extends the Longevity of Yeast and Mammalian Cells via Antioxidative Stress and Mitophagy Induction

   Antioxidants (Basel, Switzerland)·23 Jan 2022

More on Autophagy

1. Inokosterone increases cell survival in mammals cells.

   “Furthermore, it can enhance the survival ability of mammalian cells.”

   Cellsmammalian cells

   Inokosterone from Gentiana rigescens Franch Extends the Longevity of Yeast and Mammalian Cells via Antioxidative Stress and Mitophagy Induction

   Antioxidants (Basel, Switzerland)·23 Jan 2022

1. Inokosterone extends replicative and chronological lifespan in yeast cells.

   “Inokosterone from G. rigescens Franch extended not only the replicative lifespan of K6001 yeast but also the chronological lifespan of YOM36 yeast.”

   CellsK6001 and YOM36 yeast, respectively

   Inokosterone from Gentiana rigescens Franch Extends the Longevity of Yeast and Mammalian Cells via Antioxidative Stress and Mitophagy Induction

   Antioxidants (Basel, Switzerland)·23 Jan 2022