HIV infection

1. HIV infection has no effect on plasma ADRD biomarkers in humans.

   “There were no statistically significant differences in p ‐tau217/Aβ 42 , Aβ 42/40, GFAP, or NfL by HIV serostatus”

   Humanswell‐treated on ARTs50% femalesn = 576

   Chronic HIV Infection Association with Cognition and ADRD Plasma Biomarkers in Uganda

   AAIC 2025 abstract·24 Dec 2025

More on Plasma ADRD biomarkers

1. HIV infection has no effect on cognitive function in humans.

   “otherwise cognitive performance was comparable between groups including composite scores, cognitive domains, and individual tests”

   Humanswell‐treated on ARTs50% femalesn = 576

   Chronic HIV Infection Association with Cognition and ADRD Plasma Biomarkers in Uganda

   AAIC 2025 abstract·24 Dec 2025

1. HIV infection improves animal fluency in humans.

   “PLWH had higher scores on animal fluency”

   Humanswell‐treated on ARTs50% femalesn = 576

   Chronic HIV Infection Association with Cognition and ADRD Plasma Biomarkers in Uganda

   AAIC 2025 abstract·24 Dec 2025

1. HIV infection increases inflammation in human cells.

   “upregulation of inflammatory genes and downregulation of proliferative genes while maintaining mTOR signaling”

   Cellsin microglia

   HIV infection in microglia leads to senescence, triggering activation of neurotoxicity pathways

   bioRxiv : the preprint server for biology·8 May 2025Preprint

More on Inflammation

1. HIV infection activates p53–p21 pathway in human cells.

   “Both processes were characterized by p53 pathway activation”

   Cellsin microglia

   HIV infection in microglia leads to senescence, triggering activation of neurotoxicity pathways

   bioRxiv : the preprint server for biology·8 May 2025Preprint

More on p53–p21 pathway

1. HIV infection induces cellular senescence in human cells.

   “HIV infection induces a pattern of cellular senescence, with strong parallels to the transcriptomic signature of normal aging.”

   Cellsin ex vivo and in vivo microglia

   HIV infection in microglia leads to senescence, triggering activation of neurotoxicity pathways

   bioRxiv : the preprint server for biology·8 May 2025Preprint

More on Cellular senescence

1. HIV infection is associated with disability in humans (50.9% vs 40.6%, p<0.001).

   “The prevalence of disability was 50.9% among PLWH and 40.6% among controls (p<0.001).”

   Humans

   Cognitive and mental health significantly contribute to disability in people ageing with HIV in Asia: an observational case-control study

   Journal of the International AIDS Society·29 Oct 2025