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High load resistance exercise

High load resistance exercise has been studied in 2 papers since 2022: 2 trials in people. The newest paper, Oct 14, 2022: “Acute effects of low load resistance training with blood flow restriction on serum growth hormone, insulin-like growth factor-1, and testosterone in patients with mild to moderate unilateral knee osteoarthritis”.

Intervention

2 papers study it2 findingsUpdated

See all 2 papers on high load resistance exercise

At a glance

The findings reach people, from one lab or study. 1 lab in 1 country.

“Several important anabolic pathways including PI3K-Akt and MAPK pathways were significantly upregulated at 1 and 4 h post-exercise.”
Supplementation of Specific Collagen Peptides Following High-Load Resistance Exercise Upregulates Gene Expression in Pathways Involved in Skeletal Muscle Signal TransductionFrontiers in physiology2022doi:10.3389/fphys.2022.838004

None of its findings points the other way.

Humans: a single group. Cells, worms or flies and mice: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Human trial2

What did studies of high load resistance exercise find?

2

Studies of high load resistance exercise measured 2 outcomes: MAPK/ERK signaling and PI3K–AKT signaling.

MAPK/ERK signaling

upin humans1

1 study

  1. High load resistance exercise increases MAPK/ERK signaling in humans (1 and 4 h post exercise).

    “Several important anabolic pathways including PI3K-Akt and MAPK pathways were significantly upregulated at 1 and 4 h post-exercise.”

    Human trial1 and 4 h post exerciseskeletal musclemales

    Supplementation of Specific Collagen Peptides Following High-Load Resistance Exercise Upregulates Gene Expression in Pathways Involved in Skeletal Muscle Signal Transduction

    Frontiers in physiology

More on MAPK/ERK signaling

PI3K–AKT signaling

upin humans1

1 study

  1. High load resistance exercise increases PI3K–AKT signaling in humans (1 and 4 h post exercise).

    “Several important anabolic pathways including PI3K-Akt and MAPK pathways were significantly upregulated at 1 and 4 h post-exercise.”

    Human trial1 and 4 h post exerciseskeletal musclemales

    Supplementation of Specific Collagen Peptides Following High-Load Resistance Exercise Upregulates Gene Expression in Pathways Involved in Skeletal Muscle Signal Transduction

    Frontiers in physiology

More on PI3K–AKT signaling

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