High-intensity functional training

High-intensity functional training has been studied in 4 papers since 2023: 4 trials in people; 3 in the past year. The newest story, Oct 23, 2026: “High-intensity functional training linked to lower markers in 12 men”.

Intervention

4 papers study it6 findingsUpdated

“reductions of GDF15 levels in both training groups (p < 0.05).”
Astaxanthin Supplemented with High-Intensity Functional Training Decreases Adipokines Levels and Cardiovascular Risk Factors in Men with ObesityNutrients2023doi:10.3390/nu15020286

None of its findings points the other way.

  • 3 independent labs in 3 countries
  • Funders: Iran National Science Foundation and 2 more
  • Human trial4

What did studies of High-intensity functional training find?

5

Studies of High-intensity functional training measured 5 outcomes; the most studied are physical function (2 studies), body fat percentage (1) and FGF21 (1).

Physical function

upin humans2

2 studies
  1. High-intensity functional training improves physical function in humans.

    “Published studies show that both forms of complex exercise can produce measurable functional adaptation”

    Review

    From Genetic Susceptibility to Modifiable Biology: Epigenetic Plasticity, Artificial Intelligence, and Badminton as a Model of Healthy Aging

    Preprints.orgPreprint

  2. High-intensity functional training improves physical function in humans.

    “SPPB score and PTS improved significantly in the BCT and HIFT groups, and were significantly different from the CG.”

    Human trialsix calisthenic exercises24 training sessions8-weekfemales

    Comparison of Balance, Physical Performance, and Plantar Tactile Sensory of Older Women Submitted to Balance Circuit Training and High-Intensity Functional Training: A Randomized Clinical Trial

    Research in gerontological nursing

Body fat percentage

downin humans1

1 study
  1. High-intensity functional training decreases body fat percentage in humans.

    “Furthermore, body fat percentage, fasting blood glucose, HbA1c, blood lipids, and LDL-C decreased, whereas skeletal muscle mass and HDL increased (P < 0.001).”

    Human trialmetabolic syndrome50-minute sessions twice a week12 weeksmalesn = 24

    High-intensity functional training linked to lower markers in 12 men

    BMC sports science, medicine & rehabilitation

FGF21

downin humans1

1 study
  1. High-intensity functional training decreases FGF21 in humans.

    “After the intervention, both primary outcomes-serum FGF-21 and GDF-15 levels-significantly decreased in the HIFT group (P = 0.001).”

    Human trialmetabolic syndromeserum50-minute sessions twice a week12 weeksmalesn = 24

    High-intensity functional training linked to lower markers in 12 men

    BMC sports science, medicine & rehabilitation

More on FGF21

Balance

upin humans1

1 study
  1. High-intensity functional training improves balance in humans.

    “BBS score also improved significantly in the BCT and HIFT groups, but only the BCT group score was significantly different from the CG score.”

    Human trialsix calisthenic exercises24 training sessions8-weekfemales

    Comparison of Balance, Physical Performance, and Plantar Tactile Sensory of Older Women Submitted to Balance Circuit Training and High-Intensity Functional Training: A Randomized Clinical Trial

    Research in gerontological nursing

GDF-15

downin humans1

1 study
  1. High-intensity functional training decreases GDF-15 in humans.

    “reductions of GDF15 levels in both training groups (p < 0.05).”

    Human trialobesity12 weeksmalesn = 68

    Astaxanthin Supplemented with High-Intensity Functional Training Decreases Adipokines Levels and Cardiovascular Risk Factors in Men with Obesity

    Nutrients

More on GDF-15

Funding

1 grant since 2025

National Institute for Health Research£306.2k

Latest

Nov 2025: 1Dec 2025: 0Jan 2026: 1Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 1Aug 2026: 0Sep 2026: 0Oct 2026: 03 papers in 12 months
BMC Sports Science, Medicine & Rehabilitation

High-intensity functional training linked to lower markers in 12 men

A randomized trial in 24 men with metabolic syndrome linked twice-weekly high-intensity functional exercise for 12 weeks to lower levels of two metabolic stress proteins.A randomized trial in 24 men with metabolic syndrome linked twice-weekly high-intensity functional exercise for 12 weeks to lower levels of two metabolic stress proteins.

Randomized trial · 24 peopleInterventions