High energy diet

1. High energy diet increases Interleukin-8 in O. aries.

   “Obese animals exhibited elevated CSF IL-8, TNF-α, MIP-1α, and IP-10, alongside upregulation of miR-155-5p, miR-21-5p, miR-125b-5p, and miR-223-3p.”

   Animalsin diet-induced obese ewescerebrospinal fluid14-weekfemales

   Tracking CSF inflammatory signatures in an ovine model of leptin resistance

   Scientific reports·Jul 17, 2026

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1. High energy diet induces obesity in mice (+41.2% in males, +49.6% in females).

   “both sexes developed remarkable obesity after 50 weeks of age with 41.2% (males) and 49.6% (females) increasing in maximum body weight”

   Animalsapproximately 3 years

   Effect of the energy density of non-purified diets on reproduction, obesity, alopecia and aging in mice

   Jikken dobutsu. Experimental animals·Oct 1, 1991

More on Obesity

1. High energy diet shortens lifespan in mice.

   “survival rate after 50 weeks of age decreased earlier and life span was shortened”

   Animalsapproximately 3 years

   Effect of the energy density of non-purified diets on reproduction, obesity, alopecia and aging in mice

   Jikken dobutsu. Experimental animals·Oct 1, 1991