Hexarelin
Hexarelin has been studied in 287 papers since 1994: 91 trials and 16 observational studies in people, 103 in animals, 45 in cells, 26 reviews; 1 in the past year. It has not reached trials in people.
“In E the GH response to 3 micrograms/kg HEX or GHRH were clearly higher than those to 2 micrograms/kg.”
None of its findings points the other way.
- 3 independent labs in 1 country
- Human trial7
- Animals11
What did studies of Hexarelin find?
12Studies of Hexarelin measured 12 outcomes; the most studied are muscle fiber firing capacity (1 study), sodium channel conductance (1) and sodium channel current kinetics (1).
Muscle fiber firing capacity
upin rats1
1 study
Muscle fiber firing capacity
upin rats1
Hexarelin improves muscle fiber firing capacity in rats.
“Moreover, hexarelin restored the firing capacity of fast-twitch muscle fibers, as did GH in previous studies.”
Animalsfast-twitch skeletal muscle fiber4 weeks
The Journal of pharmacology and experimental therapeutics
Sodium channel conductance
no changein rats1
1 study
Sodium channel conductance
no changein rats1
Hexarelin has no effect on sodium channel conductance in rats.
“Chronic treatment of aged rats with either GH or hexarelin restored current kinetics but not channel conductance and density.”
Animalsfast-twitch skeletal muscle fiber4 weeks
The Journal of pharmacology and experimental therapeutics
Sodium channel current kinetics
upin rats1
1 study
Sodium channel current kinetics
upin rats1
Hexarelin improves sodium channel current kinetics in rats.
“Chronic treatment of aged rats with either GH or hexarelin restored current kinetics but not channel conductance and density.”
Animalsfast-twitch skeletal muscle fiber4 weeks
The Journal of pharmacology and experimental therapeutics
GH secretion
upin humans1
1 study
GH secretion
upin humans1
Hexarelin increases GH secretion in humans (GH response: 336.7, 742.8 and 1205.1 micrograms/L/h at 1.0, 2.0 and 3.0 micrograms/kg).
“In E the GH response to 3 micrograms/kg HEX or GHRH were clearly higher than those to 2 micrograms/kg.”
Human trialIncreasing hexarelin dosessynthetic hexapeptide1.0, 2.0 and 3.0 micrograms/kgn = 16
Pituitary
IGF-1
no changein rats1
1 study
IGF-1
no changein rats1
Hexarelin has no effect on IGF-1 in rats.
“Treatments with Hexa failed to alter the circulating levels of IGF-1.”
Animals80 micrograms/kg-130 and 60 days
Effect of long-term administration of Hexarelin on the somatotrophic axis in aged rats
Pharmacological research
Somatostatin mRNA
downin rats1
1 study
Somatostatin mRNA
downin rats1
Hexarelin decreases somatostatin mRNA in rats (To 'young' levels).
“administration of Hexa for 30 or 60 days brought the concentrations of somatostatin mRNA of aged rats to 'young' levels.”
Animalshypothalamus80 micrograms/kg-130 or 60 days
Effect of long-term administration of Hexarelin on the somatotrophic axis in aged rats
Pharmacological research
Growth hormone response
upin rats1
1 study
Growth hormone response
upin rats1
Hexarelin increases growth hormone response in rats.
“elicited a greater GH response in rats chronically treated with the peptide than in those receiving a placebo.”
AnimalsAcute Hexarelin challenge following chronic treatment, compared with placebo80 micrograms/kg-130 and 60 days
Effect of long-term administration of Hexarelin on the somatotrophic axis in aged rats
Pharmacological research
Muscle morphological and biochemical indices
upin dogs1
1 study
Muscle morphological and biochemical indices
upin dogs1
Hexarelin improves muscle morphological and biochemical indices in dogs (Improvement in three of six old dogs).
“In three of six old dogs, HEXA induced an improvement of some morphological and biochemical muscular indices”
Animalsmuscle500 micrograms/kg/die16 weeksn = 6
The journals of gerontology. Series A, Biological sciences and medical sciences
Alkaline phosphatase
no changein dogs1
1 study
Alkaline phosphatase
no changein dogs1
Hexarelin has no effect on alkaline phosphatase in dogs.
“Bone formation apparently was not affected since unchanged levels of alkaline phosphatase were recorded.”
Animals500 micrograms/kg/die16 weeksn = 6
The journals of gerontology. Series A, Biological sciences and medical sciences
Lysylpyridinoline
downin dogs1
1 study
Lysylpyridinoline
downin dogs1
Hexarelin decreases lysylpyridinoline in dogs.
“HEXA apparently reduced bone resorption since it significantly decreased the urinary concentration of lysylpyridinoline, a bone matrix component.”
Animals500 micrograms/kg/die16 weeksn = 6
The journals of gerontology. Series A, Biological sciences and medical sciences