Heterochronic white adipose tissue transplantation

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Animals1

Outcomes

Collagen deposition

upin mice1

1 study

Heterochronic white adipose tissue transplantation increases collagen deposition in mice.
“Mitochondrial abundance and morphology remained unchanged, while collagen deposition increased.”
Animalsold white adipose tissue transplanted into a young bodysubcutaneous white adipose tissue
Rejuvenation of white adipose tissue in a longitudinal heterochronic transplantation model
bioRxiv : the preprint server for biology29 Dec 2025Preprint

Mitochondrial abundance and morphology

no changein mice1

1 study

Heterochronic white adipose tissue transplantation has no effect on mitochondrial abundance and morphology in mice.
“Mitochondrial abundance and morphology remained unchanged”
Animalsold white adipose tissue transplanted into a young bodysubcutaneous white adipose tissue
Rejuvenation of white adipose tissue in a longitudinal heterochronic transplantation model
bioRxiv : the preprint server for biology29 Dec 2025Preprint

Lipid droplet size

downin mice1

1 study

Heterochronic white adipose tissue transplantation decreases lipid droplet size in mice.
“Molecular rejuvenation was further supported by architectural changes toward a youthful state, including reduced lipid droplet size and decreased cellular heterogeneity.”
Animalsold white adipose tissue transplanted into a young bodysubcutaneous white adipose tissue
Rejuvenation of white adipose tissue in a longitudinal heterochronic transplantation model
bioRxiv : the preprint server for biology29 Dec 2025Preprint

thermogenesis

upin mice1

1 study

Heterochronic white adipose tissue transplantation activates thermogenesis in mice.
“accompanied by coordinated activation of canonical and previously unrecognized thermogenic pathways.”
Animalsold white adipose tissue transplanted into a young bodysubcutaneous white adipose tissue
Rejuvenation of white adipose tissue in a longitudinal heterochronic transplantation model
bioRxiv : the preprint server for biology29 Dec 2025Preprint

Predicted biological age

downin mice1

1 study

Heterochronic white adipose tissue transplantation decreases predicted biological age in mice.
“Epigenetic and transcriptomic clocks revealed a reduction of predicted age”
Animalsold white adipose tissue transplanted into a young bodysubcutaneous white adipose tissue
Rejuvenation of white adipose tissue in a longitudinal heterochronic transplantation model
bioRxiv : the preprint server for biology29 Dec 2025Preprint

Latest

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bioRxiv9 Jan

Rejuvenation of white adipose tissue in a longitudinal heterochronic transplantation model

Preprint: experiments in miceInterventions

Paper

Heterochronic white adipose tissue transplantation

Outcomes

Latest

Rejuvenation of white adipose tissue in a longitudinal heterochronic transplantation model

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