Heme
- 1 lab
- Animals1
Outcomes
3Cellular senescence
upin mice1upin reviews1
2 studies
Cellular senescence
upin mice1upin reviews1
Heme induces cellular senescence.
“heme in red meat contributes to CSEN as it catalyzes the formation of genotoxic species in the colon.”
Review
Cellular Senescence Triggered by Food and Environmental Genotoxins
International journal of molecular sciences4 Mar 2026
Heme induces cellular senescence in mice.
“elevated levels of heme, a byproduct of hemolysis, strongly correlate with increased endothelial senescence and impaired cardiac function.”
Animalsin sepsis
Heme drives cardiac endothelial senescence in sepsis via STING activation
Cell death & disease18 Dec 2025
cGAS–STING signalling
upin mice1
1 study
cGAS–STING signalling
upin mice1
Heme activates cGAS–STING signalling in mice.
“heme acts as a novel ligand for STING, exacerbating bacterial infection-induced STING polymerization and activation, thereby promoting endothelial senescence.”
Animalsin bacterial infection
Heme drives cardiac endothelial senescence in sepsis via STING activation
Cell death & disease18 Dec 2025
Cardiac function
downin mice1
1 study
Cardiac function
downin mice1
Heme impairs cardiac function in mice.
“elevated levels of heme, a byproduct of hemolysis, strongly correlate with increased endothelial senescence and impaired cardiac function.”
Animalsin sepsis
Heme drives cardiac endothelial senescence in sepsis via STING activation
Cell death & disease18 Dec 2025