HCW9218

1. HCW9218 improves lung development in mice.

   “Treatment with HCW9218 prevented senescent cell accumulation and rescued lung development in the hyperoxia mouse model.”

   Animalshyperoxia modellung

   Natural killer cell TGF-β signaling regulates senolytic activity and vascular patterning in the postnatal lung

   bioRxiv (Cold Spring Harbor Laboratory)·Sep 4, 2025Preprint

1. HCW9218 decreases senescent cells in mice.

   “Treatment with HCW9218 prevented senescent cell accumulation and rescued lung development in the hyperoxia mouse model.”

   Animalshyperoxia modellung

   Natural killer cell TGF-β signaling regulates senolytic activity and vascular patterning in the postnatal lung

   bioRxiv (Cold Spring Harbor Laboratory)·Sep 4, 2025Preprint

More on Senescent cells

1. HCW9218 improves physical function in mice.

   “Long-term survival studies also showed that HCW9218 treatment improved physical performance without compromising the health span of naturally aged mice.”

   Animalsnaturally aged mice

   Immunotherapeutic approach to reduce senescent cells and alleviate senescence-associated secretory phenotype in mice

   Aging cell·Mar 26, 2023

1. HCW9218 improves insulin resistance in mice.

   “subcutaneous administration of HCW9218 reduced senescent islet β cells and SASP resulting in improved glucose tolerance, insulin resistance, and aging index”

   Animalsdiabetic db/db mouse model

   Immunotherapeutic approach to reduce senescent cells and alleviate senescence-associated secretory phenotype in mice

   Aging cell·Mar 26, 2023

1. HCW9218 decreases cellular senescence in mice.

   “subcutaneous administration of HCW9218 reduced senescent islet β cells and SASP resulting in improved glucose tolerance, insulin resistance, and aging index”

   Animalsdiabetic db/db mouse model

   Immunotherapeutic approach to reduce senescent cells and alleviate senescence-associated secretory phenotype in mice

   Aging cell·Mar 26, 2023

More on Cellular senescence