AgingResearch.NewsJoin free

Handelin

Intervention

1 paper2 findings

PubChem 3085251MeSH C053046

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Education Department of Jiangxi Province and 3 more
  • Animals1

Outcomes

2

Muscle cross-sectional area

upin mice1

1 study

  1. Handelin increases muscle cross-sectional area in mice.

    “In aged mice, handelin slightly increased the weight of the tibialis anterior muscle (P = 0.06) and CSA of the tibialis anterior and gastrocnemius muscles (P < 0.0001).”

    Animals

    Handelin alleviates cachexia- and aging-induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation

    Journal of cachexia, sarcopenia and muscle27 Nov 2023

Motor function

upin mice1

1 study

  1. Handelin improves motor function in mice.

    “In LPS-treated mice, handelin increased body weight (P < 0.05), the weight (P < 0.01) and cross-sectional area (CSA) of the soleus muscle (P < 0.0001) and improved motor function (P < 0.05).”

    AnimalsLPS-treated mice

    Handelin alleviates cachexia- and aging-induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation

    Journal of cachexia, sarcopenia and muscle27 Nov 2023

Latest

Related