GW9662
Across all fields, 1 paper: none in people yet, 1 in animals
- 2 independent labs in 2 countries
- Funders: National Institute on Aging and 1 more
- Animals1
Outcomes
4KL
downin rats1
1 study
KL
downin rats1
GW9662 decreases KL in rats.
“GW9226/estrogen co-treatment interfered with the regulatory effect of estrogen on Klotho.”
Animalsin estrogen-treated ovariectomized stressed ratsfemales
Human cell
Inflammation
downin mouse cells1
1 study
Inflammation
downin mouse cells1
GW9662 inhibits inflammation in mouse cells.
“GW9662 treatment decreased the expression of several inflammation-related genes”
Cellsin vitro stromal stem cells
The journals of gerontology. Series A, Biological sciences and medical sciences
Immune cell composition
no changein mice1
1 study
Immune cell composition
no changein mice1
GW9662 has no effect on immune cell composition in mice.
“inhibition of PPARγ had no significant effect on marrow and spleen immune cell composition in aged female mice”
Animalsbone marrow and spleenfemales
The journals of gerontology. Series A, Biological sciences and medical sciences
Bone volume
downin mice1
1 study
Bone volume
downin mice1
GW9662 decreases bone volume in mice.
“treatment with PPARγ antagonist GW9662 for 6 weeks reduced bone volume and trabecular number and increased trabecular spacing”
Animalsbone6 weeksfemales
The journals of gerontology. Series A, Biological sciences and medical sciences
Latest
1 paper in 12 monthsInvestigative Ophthalmology & Visual Science
Activation of PPARγ Attenuates Age-Related Lacrimal Gland Dysfunction by Alleviating Endoplasmic Reticulum Stress-Mediated Ferroptosis
Experiments in miceInterventions
Journal of Pharmaceutical Analysis
1,8-Cineole ameliorates vascular endothelial senescence in diabetes mellitus by directly targeting and deubiquitinating PPAR-γ in vivo and in vitro
Experiments in miceInterventions
Experimental Gerontology
α-Lipoic acid mitigates age-related cognitive decline by modulating PPARγ/NF-κB-mediated neuroinflammation
Experiments in miceInterventions
Journal of Agricultural and Food Chemistry
Myricetin Alleviates Silica-Mediated Lung Fibrosis via PPARγ-PGC-1α Loop and Suppressing Mitochondrial Senescence in Epithelial Cells
Experiments in micePulmonary fibrosis
The Journals of Gerontology, Series A
Effects of Systemic Peroxisome Proliferator-Activated Receptor Gamma Inhibition on Bone and Immune Cells in Aged Female Mice
Experiments in miceBones and joints
Journal of Molecular Neuroscience
rhEPO Upregulates the PPARγ Pathway in Long-term Cultured Primary Nerve Cells via PI3K/Akt to Delay Cell Senescence
Experiments in rat cellsInterventions
Biomedicine & Pharmacotherapy
Therapeutic effects of honokiol on motor impairment in hemiparkinsonian mice are associated with reversing neurodegeneration and targeting PPARγ regulation
Experiments in miceInterventions