GSK690693

1. GSK690693 induces apoptosis in flies.

   “consequently activating FOXO, GSK-3β and apoptosis to modulate longevity of flies.”

   Model organisms

   Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway

   Mechanisms of ageing and development·Jan 20, 2022

More on Apoptosis

1. GSK690693 inhibits PI3K–AKT signaling in flies.

   “GSK690693 treatment reduced the activation of AKT and ERK”

   Model organisms

   Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway

   Mechanisms of ageing and development·Jan 20, 2022

More on PI3K–AKT signaling

1. GSK690693 has no effect on physical activity in flies.

   “but not in physical activity or starvation resistance.”

   Model organisms

   Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway

   Mechanisms of ageing and development·Jan 20, 2022

1. GSK690693 increases autophagy in flies.

   “Effect of GSK690693 for lifespan extension has been primarily related to the improvements in oxidative resistance, intestinal integrity and increased autophagy”

   Model organisms

   Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway

   Mechanisms of ageing and development·Jan 20, 2022

More on Autophagy

1. GSK690693 extends lifespan in flies.

   “AKT inhibitor GSK690693 can extend lifespan in Drosophila irrespective of start of the treatment from the beginning of life or the mid-life.”

   Model organisms

   Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway

   Mechanisms of ageing and development·Jan 20, 2022