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Galactic cosmic radiation

Intervention

4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Aeronautics and Space Administration and 1 more

Outcomes

4

Intestinal fatty acid-binding protein

upin mice1

1 study

  1. Galactic cosmic radiation increases intestinal fatty acid-binding protein in mice.

    “Biochemical markers supported intestinal injury, with decreased serum citrulline and increased intestinal fatty acid-binding protein (I-FABP), indicating barrier compromise.”

    Animalsafter 50 cGy 33-ion mixed-field GCR simulationserum50 cGy5 months

    cGAS/STING Pathway Mediates Accelerated Intestinal Cell Senescence and SASP After GCR Exposure in Mice

    Cells11 Nov 2025

More on Intestinal fatty acid-binding protein

cGAS–STING signalling

upin mice1

1 study

  1. Galactic cosmic radiation activates cGAS–STING signalling in mice.

    “Targeted molecular study revealed persistent activation of the cGAS-STING pathway, with elevated cGAS, STING, pTBK1, pIKKα/β, and nuclear pIRF3, pIRF7, and p65”

    Animalsafter 50 cGy 33-ion mixed-field GCR simulationintestine50 cGy5 months

    cGAS/STING Pathway Mediates Accelerated Intestinal Cell Senescence and SASP After GCR Exposure in Mice

    Cells11 Nov 2025

More on cGAS–STING signalling

Cellular senescence

upin mice1

1 study

  1. Galactic cosmic radiation induces cellular senescence in mice.

    “Intestinal epithelial cells (IECs) exhibited pronounced senescence, marked by increased SA-β-gal activity, p16 upregulation, LaminB1 loss, and induction of senescence-associated secretory phenotype (SASP) cytokines”

    Animalsafter 50 cGy 33-ion mixed-field GCR simulationintestinal epithelial cells50 cGy5 months

    cGAS/STING Pathway Mediates Accelerated Intestinal Cell Senescence and SASP After GCR Exposure in Mice

    Cells11 Nov 2025

More on Cellular senescence

Oxidative stress and ROS signalling

upin mice1

1 study

  1. Galactic cosmic radiation induces oxidative stress and ROS signalling in mice.

    “GCRsim induced sustained DNA double-strand breaks (DSBs) and oxidative stress, as shown by elevated γH2AX foci and 4-HNE staining.”

    Animalsafter 50 cGy 33-ion mixed-field GCR simulationintestinal epithelial cells50 cGy5 months

    cGAS/STING Pathway Mediates Accelerated Intestinal Cell Senescence and SASP After GCR Exposure in Mice

    Cells11 Nov 2025

More on Oxidative stress and ROS signalling

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