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Frail plasma

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Fondazione Cariplo and 1 more
  • Humans1

Outcomes

2

Nuclear DNA damage

upin human cells1

1 study

  1. Frail plasma increases nuclear DNA damage in human cells.

    “we showed significant functional impairment and nuclear DNA damage in the treated cells of the renal stem compartment.”

    Cellsallogeneic cells treated with plasma from older individuals with frailtyrenal stem/progenitor cells

    Impairment of Renal and Hematopoietic Stem/Progenitor Cell Compartments in Frailty Syndrome: Link With Oxidative Stress, Plasma Cytokine Profiles, and Nuclear DNA Damage

    The journals of gerontology. Series A, Biological sciences and medical sciences27 Jul 2024

Renal stem/progenitor cell function

downin human cells1

1 study

  1. Frail plasma impairs renal stem/progenitor cell function in human cells.

    “we showed significant functional impairment and nuclear DNA damage in the treated cells of the renal stem compartment.”

    Cellsallogeneic cells treated with plasma from older individuals with frailtyrenal stem/progenitor cells

    Impairment of Renal and Hematopoietic Stem/Progenitor Cell Compartments in Frailty Syndrome: Link With Oxidative Stress, Plasma Cytokine Profiles, and Nuclear DNA Damage

    The journals of gerontology. Series A, Biological sciences and medical sciences27 Jul 2024

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