Ferric ammonium citrate

2 papers2 findings

2 independent labs in 2 countries

Funders: American Heart Association and 2 more

Humans2

Outcomes

2

Extracellular matrix remodelling

upin human cells1

1 study

Ferric ammonium citrate increases extracellular matrix remodelling in human cells.
“FAC exposure impaired iron metabolism and enhanced ECM deposition.”
Cellsin hASM cells100 μM72 h
Dysregulated iron metabolism in remodeling of aging asthmatic human airways
American journal of physiology. Cell physiologyJul 29, 2026

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Cellular senescence

upin cells1

1 study

Ferric ammonium citrate increases cellular senescence in cells.
“Ferric ammonium citrate (50 μM) upregulated gamma-H2A.X variant histone and increased the senescence markers in HG-treated cells.”
Cellsin HG-treated renal cells50 μM
Excess iron accumulation mediated senescence in diabetic kidney injury
Journal of biochemical and molecular toxicologyMar 14, 2024

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Latest

4 in 12 months

American Journal of Physiology Cell PhysiologyJul 29

Dysregulated iron metabolism in remodeling of aging asthmatic human airways

Study in peopleExtracellular matrix remodelling

Investigative Ophthalmology & Visual ScienceApr 14

Modulation of Iron-Induced Glucose Metabolic Reprogramming Alleviates Retinal Pigment Epithelial Cell Senescence

Experiments in miceCellular senescence

JMIR Research ProtocolsJan 13

The Role of Iron-Overloaded Macrophages in Mesenchymal Stem Cell Senescence and Anemia in Myelodysplastic Syndromes: Protocol for an In Vitro Study

Study protocolCellular senescence

Rejuvenation ResearchDec 5

Nicotinamide Mononucleotide Reduces Iron in BV-2 Cell by Up-Regulating Ferroportin 1 via Inhibiting the IL-6/STAT3/Hepcidin Pathway

Experiments in mouse cellsNicotinamide mononucleotide

Experimental GerontologyJul 17

ATF3 as a molecular nexus linking ferroptosis regulation to sarcopenia pathogenesis via PI3K/Akt pathway activation

Experiments in miceFerroptosis

NanomedicineSep 4

Nanoparticle-delivered quercetin exhibits enhanced efficacy in eliminating iron-overloaded senescent chondrocytes

Experiments in human cellsQuercetin

Journal of Biochemical and Molecular ToxicologyMar 14

Excess iron accumulation mediated senescence in diabetic kidney injury

Study in peopleCellular senescence

Acta Pharmacologica SinicaSep 7

Cell senescence induced by toxic interaction between α-synuclein and iron precedes nigral dopaminergic neuron loss in a mouse model of Parkinson's disease

Experiments in miceCellular senescence

Pharmaceutical BiologyApr 4

Schisandrin B promotes senescence of activated hepatic stellate cell via NCOA4-mediated ferritinophagy

Experiments in animalsInterventions

Aging CellMar 27

Deterioration of hematopoietic autophagy is linked to osteoporosis

Experiments in animalsMechanisms