Lifespan
upin worms2downin worms1
Ethidium bromide extends lifespan in worms.
“Specific antibiotics targeting mitochondrial translation and ethidium bromide (which impairs mitochondrial DNA transcription) pharmacologically mimic mrp knockdown and extend worm lifespan”
Model organismspharmacologically mimic mrp knockdown
Mitonuclear protein imbalance as a conserved longevity mechanism
Nature23 May 2013
Ethidium bromide shortens lifespan in worms.
“but decreases, when used after the beginning of adult stage.”
Reviewused after the beginning of adult stage
Mitochondrial DNA-deficient models and aging
Annals of the New York Academy of Sciences1 Apr 2007
Ethidium bromide extends lifespan in worms.
“In C. elegans, EB, when used during larval development, increases life span”
Reviewused during larval development
Mitochondrial DNA-deficient models and aging
Annals of the New York Academy of Sciences1 Apr 2007
cGAS phase separation
downin mouse cells1
Ethidium bromide inhibits cGAS phase separation in mouse cells.
“ethidium bromide (EtBr) markedly reduced cytosolic mtDNA accumulation caused by co-exposure, suppressed cGAS phase separation”
CellsLead and angiotensin II co-exposure; inhibition of mitochondrial DNA replication
Environmental pollution (Barking, Essex : 1987)27 Jun 2026
An experiment in rats linked the chemical’s effects to fumarate, a substance involved in metabolism, and DNA escaping from cells’ energy-producing structures.An experiment in rats linked the chemical’s effects to fumarate, a substance involved in metabolism, and DNA escaping from cells’ energy-producing structures.