Essential metals

2 papers1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Anhui Medical University and 1 more

Humans2

Outcomes

KDM biological age acceleration

downin humans1

1 study

Essential metals decrease KDM biological age acceleration in humans (-1.77-year (95% CI = -2.43, -1.12)).
“a quartile increase in the EM mixture was significantly associated with a 1.77-year (95% CI = -2.43, -1.12) decrease in KDM-accel”
Humansn = 2,787
Association of the essential metal mixture with biological aging in Chinese older adults: Investigating superoxide dismutase as a potential mediator
Ecotoxicology and environmental safety18 Feb 2026