Erianin

1. Erianin extends lifespan.

   “erianin synergized with anti-PD-L1 therapy to achieve superior tumor control and prolonged survival in vivo”

   Animalscombined with anti-PD-L1 therapy in senescent tumor-bearing mice

   Erianin Potentiates the Efficacy of Immune Checkpoint inhibitor in Cholangiocarcinoma by Inhibiting FAK-mediated cell growth and senolytic activity

   Preprint·30 Mar 2026Preprint

1. Erianin inhibits PTK2 in cells.

   “Erianin effectively inhibited FAK phosphorylation”

   Cellsin CCA cells

   Erianin Potentiates the Efficacy of Immune Checkpoint inhibitor in Cholangiocarcinoma by Inhibiting FAK-mediated cell growth and senolytic activity

   Preprint·30 Mar 2026Preprint

More on PTK2

1. Erianin inhibits senescence-associated secretory phenotype (SASP) in cells.

   “reduced SASP factor secretion”

   Cellsin CCA cells

   Erianin Potentiates the Efficacy of Immune Checkpoint inhibitor in Cholangiocarcinoma by Inhibiting FAK-mediated cell growth and senolytic activity

   Preprint·30 Mar 2026Preprint

More on Senescence-associated secretory phenotype (SASP)

1. Erianin decreases senescent cells in cells.

   “erianin eliminated senescent cells by promoting apoptosis and reduced SASP factor secretion”

   Cellsin CCA cells

   Erianin Potentiates the Efficacy of Immune Checkpoint inhibitor in Cholangiocarcinoma by Inhibiting FAK-mediated cell growth and senolytic activity

   Preprint·30 Mar 2026Preprint

More on Senescent cells