ANTI-PD-L1 antibody

Intervention

4 papers2 findings

  • 2 independent labs in 1 country
  • Funder: Japan Society for the Promotion of Science
  • Animals3

Outcomes

2

Immune response

upin mice1

1 study
  1. ANTI-PD-L1 antibody increases immune response in mice.

    “Anti-PD-L1 treatment in aged mice enhanced antitumor immunity, but preferentially increased PD-1+ CD8T in both TDLNs and TME.”

    AnimalsSCCVII squamous cell carcinoma model

    Impaired PD-1 expression in tumor-infiltrating senescent CD8⁺ T cells is reversed by PD-L1 blockade in a murine squamous cell carcinoma model

    Journal of oral biosciences7 Jan 2026

More on Immune response

Tumor growth

downin mice1

1 study
  1. ANTI-PD-L1 antibody decreases tumor growth in mice.

    “When SenoVaxTM was administered in combination with anti-PD-L1 or anti-CTLA-4 antibodies, the data showed synergistic effects in reducing tumor growth.”

    Animalsin combination with SenoVax

    Reduction of solid tumors by senescent cell immunization

    Journal of translational medicine28 Nov 2025

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