Enrofloxacin
Enrofloxacin has been studied in 2 papers since 2018: none in people yet, 2 in animals. The research so far is in animals. The newest paper, May 9, 2025: “Discovery of Non-antibacterial Enrofloxacin Derivatives with Emerging Antiaging Effects through Drug Repurposing and Secondary Development”.
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: Janssen Research and Development and others
- 2 of 3 findings with company ties
- Animals2
What did studies of Enrofloxacin find?
2Studies of Enrofloxacin measured 2 outcomes; the most studied are insulin response (1 study) and lifespan (1).
Insulin response
upin macaques1upin mice1
1 study
Insulin response
upin macaques1upin mice1
Enrofloxacin improves insulin response in macaques.
“supplementation with either A. muciniphila or the antibiotic enrofloxacin, which increased the abundance of A. muciniphila, restored normal insulin response in aged mice and macaques.”
Animals
Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells
Science translational medicine
Enrofloxacin improves insulin response in mice.
“supplementation with either A. muciniphila or the antibiotic enrofloxacin, which increased the abundance of A. muciniphila, restored normal insulin response in aged mice and macaques.”
Animals
Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells
Science translational medicine
Lifespan
upin worms1
1 study
Lifespan
upin worms1
Enrofloxacin extends lifespan in worms.
“discovered that enrofloxacin could extend the lifespan in Caenorhabditis elegans.”
Model organisms
Journal of medicinal chemistry