Endotoxin

1 paper2 findings

1 lab in 1 country

Funders: Brain and Behavior Research Foundation and 7 more

Human trial1

Outcomes

2

Reward learning

downin humans1

1 study

Endotoxin decreases reward learning in humans (p = 0.04).
“endotoxin decreased PRT reward learning in both groups (p = 0.04)”
Human trial0.8 ng/kgfemales
Inflammation-induced depressed mood and reward responsivity as a function of age in female adults: a randomized controlled trial of endotoxin
Translational psychiatry26 Nov 2025

Reward sensitivity

downin humans1

1 study

Endotoxin decreases reward sensitivity in humans (p = 0.004).
“decrease in reward sensitivity in younger (p = 0.004) but not older (p = 0.43) females”
Human trial0.8 ng/kgfemales
Inflammation-induced depressed mood and reward responsivity as a function of age in female adults: a randomized controlled trial of endotoxin
Translational psychiatry26 Nov 2025

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