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Endostatin

Intervention

1 paper2 findings

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: National Institute of Diabetes and Digestive and Kidney Diseases
  • Animals1

Outcomes

2

Patency of renal microvasculature

downin mice1

1 study

  1. Endostatin decreases patency of renal microvasculature in mice.

    “Treating young mice with endostatin for 28 days showed delayed recovery of circulation after femoral artery ligation and reduced patency of renal microvasculature but no fibrosis.”

    Animalskidney28 days

    Endostatin and kidney fibrosis in aging: a case for antagonistic pleiotropy?

    American journal of physiology. Heart and circulatory physiologyApr 11, 2014

Circulation

downin mice1

1 study

  1. Endostatin impairs circulation in mice.

    “Treating young mice with endostatin for 28 days showed delayed recovery of circulation after femoral artery ligation and reduced patency of renal microvasculature but no fibrosis.”

    Animalsafter femoral artery ligation28 days

    Endostatin and kidney fibrosis in aging: a case for antagonistic pleiotropy?

    American journal of physiology. Heart and circulatory physiologyApr 11, 2014

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