Ebselen

  • 2 independent labs in 1 country
  • Animals2
  • Cells1

Outcomes

2

Auditory function

upin mice1

1 study
  1. Ebselen improves auditory function in mice.

    “Furthermore, we discovered that the small molecule drug ebselen could reduce degeneration and damage in SGNs and effectively enhance auditory function by activating autophagy”

    Animalsin SGNs

    GPX3 activates autophagy to protect cochlear spiral ganglion neurons from injury in age-related hearing loss

    Free radical biology & medicine16 Mar 2026

Testicular aging

downin animals1

1 study
  1. Ebselen decreases testicular aging.

    “PRDX1 dysfunction exacerbates testicular and systematic aging in aged mice, which can be alleviated by a 2-cysteine mimic, ebselen”

    Animalsin aged mice with PRDX1 dysfunction

    PRDX1 promotes testosterone synthesis and attenuates aging via redox regulation of ATG4B to modulate lipophagy

    Nature communications19 Nov 2025

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