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Early midgut injury

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Model organisms1

Outcomes

2

Lifespan

upin flies1

1 study

  1. Early midgut injury extends lifespan in flies.

    “early midgut injury prevents the abrupt onset of aging hyperplasia and extends lifespan in flies.”

    Model organisms

    Age mosaic of gut epithelial cells prevents aging

    Nature communications22 Jul 2025

Age-related midgut hyperplasia

downin flies1

1 study

  1. Early midgut injury prevents age-related midgut hyperplasia in flies.

    “early midgut injury prevents the abrupt onset of aging hyperplasia and extends lifespan in flies.”

    Model organismsmidgut

    Age mosaic of gut epithelial cells prevents aging

    Nature communications22 Jul 2025

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