Diphenyleneiodonium
- 1 lab in 1 country
- Funder: University of Salford Manchester
- Model organisms1
Outcomes
1Lifespan
upin worms1
1 study
Lifespan
upin worms1
Diphenyleneiodonium extends lifespan in worms.
“Similarly, DPI, an inhibitor of mitochondrial complex I and II, was capable of prolonging the median lifespan of treated worms.”
Model organisms
Antibiotics that target mitochondria extend lifespan in C. elegans
AgingNov 9, 2023
Latest
Frontiers in Physiology
Trehalose induces bladder smooth muscle hypercontractility in mice: involvement of oxidative stress and cellular senescence
Experiments in miceMuscle
Aging
Antibiotics that target mitochondria extend lifespan in C. elegans
Experiments in wormsInterventions
Biomedicine & Pharmacotherapy
Senomorphic effect of diphenyleneiodonium through AMPK/MFF/DRP1 mediated mitochondrial fission
Experiments in animalsInterventions
International Journal of Molecular Sciences
Induction of Premature Cell Senescence Stimulated by High Doses of Antioxidants Is Mediated by Endoplasmic Reticulum Stress
Experiments in cellsMechanisms
Annals of Geriatric Medicine and Research
Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression
Experiments in cellsMechanisms
Osteoarthritis and Cartilage
Lysosomal dysfunction in osteoarthritis and aged cartilage triggers apoptosis in chondrocytes through BAX mediated release of Cytochrome c
Experiments in animalsMechanisms