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Dinoprostone

Intervention

1 paper5 findings

PubChem 5280360ChEBI 15551MeSH D015232

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: California Institute for Regenerative Medicine and others
  • Animals1

Outcomes

4

Muscle strength

upin animals1

1 study

  1. Dinoprostone improves muscle strength.

    “PGE2 injections following myotoxin- or exercise-induced injury overcome the aged niche, leading to enhanced regenerative function of endogenous tissue-resident MuSCs and an increase in strength.”

    Animalsfollowing myotoxin- or exercise-induced injurymuscle

    Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength

    Cell stem cell12 Jun 2025

Endogenous muscle stem cell regenerative function

upin animals1

1 study

  1. Dinoprostone improves endogenous muscle stem cell regenerative function.

    “PGE2 injections following myotoxin- or exercise-induced injury overcome the aged niche, leading to enhanced regenerative function of endogenous tissue-resident MuSCs”

    Animalsfollowing myotoxin- or exercise-induced injurymuscle

    Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength

    Cell stem cell12 Jun 2025

Long-term muscle regenerative capacity

upin animals1

1 study

  1. Dinoprostone improves long-term muscle regenerative capacity.

    “We find that short-term exposure of aged MuSCs to PGE2 augments their long-term regenerative capacity upon transplantation.”

    Animalsfollowing transplantation of treated muscle stem cellsmuscleshort-term exposure

    Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength

    Cell stem cell12 Jun 2025

Muscle stem cell viability

upin cells1

1 study

  1. Dinoprostone increases muscle stem cell viability in cells.

    “Treatment with PGE2 alters chromatin accessibility and overcomes the dysfunctional aged MuSC fate trajectory, increasing viability and triggering cell cycle re-entry.”

    Cellsmuscle stem cell

    Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength

    Cell stem cell12 Jun 2025

Associations

1

Chromatin accessibility

mixedin cells1

1 study

  1. Dinoprostone is associated with chromatin accessibility in cells.

    “Treatment with PGE2 alters chromatin accessibility”

    Cellsmuscle stem cell

    Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength

    Cell stem cell12 Jun 2025

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