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Dihydroxy-octadecenoic acids

Dihydroxy-octadecenoic acids has been studied in 1 paper since 2023: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Feb 26, 2023: “Soluble Epoxide Hydrolase Contributes to Cell Senescence and ER Stress in Aging Mice Colon”.

Intervention

1 paper studies it2 findingsUpdated

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Heart, Lung, and Blood Institute and 3 more
  • 2 of 2 findings with company ties
  • Animals1

What did studies of Dihydroxy-octadecenoic acids find?

2

Studies of Dihydroxy-octadecenoic acids measured 2 outcomes; the most studied are ER unfolded protein response (1 study) and cell viability (1).

ER unfolded protein response

upin human cells1

1 study

  1. Dihydroxy-octadecenoic acids increase ER unfolded protein response in human cells.

    “treatment with sEH-derived linoleic acid metabolites, dihydroxy-octadecenoic acids (DiHOMEs), decreased cell viability and increased ER stress in human colon CCD-18Co cells in vitro”

    Cellscolon

    Soluble Epoxide Hydrolase Contributes to Cell Senescence and ER Stress in Aging Mice Colon

    International journal of molecular sciences

More on ER unfolded protein response

Cell viability

downin human cells1

1 study

  1. Dihydroxy-octadecenoic acids decrease cell viability in human cells.

    “treatment with sEH-derived linoleic acid metabolites, dihydroxy-octadecenoic acids (DiHOMEs), decreased cell viability”

    Cellscolon

    Soluble Epoxide Hydrolase Contributes to Cell Senescence and ER Stress in Aging Mice Colon

    International journal of molecular sciences

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