AgingResearch.NewsJoin free

PPP1R15A

Gene

1 paper3 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • 1 trial
  • Funder: Japan Society for the Promotion of Science
  • 1 of 1 trial sponsored by developers of drugs on it
  • Animals1

Effects

3

Insulin resistance

downin mice1

1 study

  1. PPP1R15A prevents insulin resistance in mice.

    “with age GADD34-deficient mice become obese, developing fatty liver followed by liver cirrhosis, hepatocellular carcinoma, and insulin resistance.”

    Animalswith age

    GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance

    Scientific reports28 Aug 2015

More on Insulin resistance

Hepatocellular carcinoma

downin mice1

1 study

  1. PPP1R15A prevents hepatocellular carcinoma in mice.

    “with age GADD34-deficient mice become obese, developing fatty liver followed by liver cirrhosis, hepatocellular carcinoma, and insulin resistance.”

    Animalswith age

    GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance

    Scientific reports28 Aug 2015

More on Hepatocellular carcinoma

Obesity

downin mice1

1 study

  1. PPP1R15A prevents obesity in mice.

    “with age GADD34-deficient mice become obese, developing fatty liver followed by liver cirrhosis, hepatocellular carcinoma, and insulin resistance.”

    Animalswith age / in aged mice

    GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance

    Scientific reports28 Aug 2015

More on Obesity

Latest

Related