Dietary fiber intake

3 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

3 independent labs in 3 countries

Funders: Biotechnology and Biological Sciences Research Council and 7 more

Humans2
Animals1

Associations

Cardiovascular disease mortality

downin humans1HR 0.69

1 study

Dietary fiber intake is associated with cardiovascular disease mortality in humans (HR = 0.69).
“Women in the highest fiber tertile had significantly lower mortality risks than those in the lowest tertile (all-cause HR = 0.85; CVD HR = 0.69).”
Humanshighest vs lowest fiber tertilefemalesn = 7,708
Association of dietary fiber intake with all-cause and cardiovascular mortality in postmenopausal U.S. women: A NHANES 1999-2018 cohort study
Maturitas23 Oct 2025

Mortality

downin humans1HR 0.85

1 study

Dietary fiber intake is associated with mortality in humans (HR = 0.85).
“Women in the highest fiber tertile had significantly lower mortality risks than those in the lowest tertile (all-cause HR = 0.85; CVD HR = 0.69).”
Humanshighest vs lowest fiber tertilefemalesn = 7,708
Association of dietary fiber intake with all-cause and cardiovascular mortality in postmenopausal U.S. women: A NHANES 1999-2018 cohort study
Maturitas23 Oct 2025

Telomere length

upin humans1

1 study

Dietary fiber intake is associated with telomere length in humans (LTL difference equivalent to 1 year of age-related change).
“Energy-adjusted fibre intake was associated with an age-related change of LTL equivalent to 1 year (P < .0001).”
HumansEnergy-adjusted dietary fibre intakeleukocyten = 143,553
Higher dietary n - 3 PUFA and fiber intake are associated with longer leukocyte telomere length: Evidence from a substitution model analysis in the UK Biobank
Nutrition research (New York, N.Y.)4 Sep 2025