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Ethinylestradiol + desogestrel + metformin

Intervention

1 paper1 finding

PubChem 5991PubChem 40973PubChem 4091ChEBI 4903ChEBI 4453ChEBI 6801

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab
  • Human trial1

Outcomes

1

Glucose

upin humans1

1 study

  1. Ethinylestradiol + desogestrel + metformin increases glucose in humans (RGM 1.15, 95% CI 1.07-1.23).

    “addition of Metformin did not mitigate this (RGM 1.15, 95% CI 1.07-1.23 for COCP+Metformin).”

    Human trialin hyperandrogenic women with PCOS and BMI >=25 kg/m26 monthsfemalesn = 80

    SAT-133 Addition of Metformin Does Not Alter Metabolic Impact of Combined Oral Contraceptive Pills in Hyperandrogenic Women with Polycystic Ovary Syndrome: Findings from COMET-PCOS Trial

    ENDO 2025 abstract22 Oct 2025

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