Ethinylestradiol + desogestrel

1 paper2 findings

PubChem 5991 PubChem 40973 ChEBI 4903 ChEBI 4453

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab

Human trial1

Outcomes

Glucose

upin humans1

1 study

Ethinylestradiol + desogestrel increases glucose in humans (RGM 1.13, 95% CI 1.05-1.22).
“2-hour glucose increased (ratio of geometric means (RGM) 1.13, 95% CI 1.05-1.22) in the COCP group”
Human trialin hyperandrogenic women with PCOS and BMI >=25 kg/m26 monthsfemalesn = 79
SAT-133 Addition of Metformin Does Not Alter Metabolic Impact of Combined Oral Contraceptive Pills in Hyperandrogenic Women with Polycystic Ovary Syndrome: Findings from COMET-PCOS Trial
ENDO 2025 abstract22 Oct 2025