Testosterone + dehydroepiandrosterone

Testosterone + dehydroepiandrosterone has been studied in 2 papers since 2017: none in people yet, 2 in animals. The research so far is in animals.

Intervention

2 papers study it216 more mention it2 findingsUpdated

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3 new papers in 30 daysSee all 218

None of its findings points the other way.

  • 1 lab in 1 country
  • Funders: National Institute on Aging and 3 more
  • Animals2

What did studies of Testosterone + dehydroepiandrosterone find?

2

Studies of Testosterone + dehydroepiandrosterone measured 2 outcomes; the most studied are recognition and working memory task performance (1 study) and daytime activity (1).

Recognition and working memory task performance

no changein rhesus monkeys1

1 study
  1. Testosterone + dehydroepiandrosterone showed no clear effect on recognition and working memory task performance in rhesus monkeys (compared with age-matched controls).

    “However, there were no differences between the androgen supplemented animals and age-matched controls.”

    Animalscompared with age-matched controlsdaily supplements∼7 monthsmales

    Effect of short-term androgen supplementation on cognitive performance in older male rhesus macaques

    Neurobiology of aging

Daytime activity

no changein rhesus monkeys1

1 study
  1. Testosterone + dehydroepiandrosterone showed no clear effect on daytime activity in rhesus monkeys.

    “However, there was no difference between the androgen-supplemented old animals and the aged-matched controls, even after 6 months of treatment.”

    Animals6 monthsmales

    Effect of androgen supplementation on 24-hour activity-rest patterns of aged male rhesus macaques

    Neurobiology of aging

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